Abstract
α-Synuclein is a major component of Lewy bodies in Parkinsons disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of α-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of α-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.
Keywords: synuclein, amyloid, aggregation, parkinsons disease
Protein & Peptide Letters
Title: α-Synuclein Aggregation
Volume: 11 Issue: 3
Author(s): Angela M. Bodles and G. Brent Irvine
Affiliation:
Keywords: synuclein, amyloid, aggregation, parkinsons disease
Abstract: α-Synuclein is a major component of Lewy bodies in Parkinsons disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of α-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of α-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.
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Cite this article as:
Bodles M. Angela and Irvine Brent G., α-Synuclein Aggregation, Protein & Peptide Letters 2004; 11 (3) . https://dx.doi.org/10.2174/0929866043407084
DOI https://dx.doi.org/10.2174/0929866043407084 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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