Abstract
Pin1, a phospho-Ser / Thr-Pro specific PPIase, participates in many biological processes. Recently, through designing substrate mimetics, or library screening, several classes of Pin1 inhibitors have been discovered. Some polyaromatic compounds, including juglone, as well as peptide mimetics containing both proline and phosphate, have been demonstrated to inhibit biological functions of Pin1.
Keywords: pin1, inhibitor, ppiase, substrate mimetics, combinatorial library, phosphorylation
Mini-Reviews in Organic Chemistry
Title: Inhibitors Targeting the Enzymatic Activity and Biological Function of Pin1
Volume: 1 Issue: 4
Author(s): Yixin Zhang
Affiliation:
Keywords: pin1, inhibitor, ppiase, substrate mimetics, combinatorial library, phosphorylation
Abstract: Pin1, a phospho-Ser / Thr-Pro specific PPIase, participates in many biological processes. Recently, through designing substrate mimetics, or library screening, several classes of Pin1 inhibitors have been discovered. Some polyaromatic compounds, including juglone, as well as peptide mimetics containing both proline and phosphate, have been demonstrated to inhibit biological functions of Pin1.
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Cite this article as:
Zhang Yixin, Inhibitors Targeting the Enzymatic Activity and Biological Function of Pin1, Mini-Reviews in Organic Chemistry 2004; 1 (4) . https://dx.doi.org/10.2174/1570193043403055
DOI https://dx.doi.org/10.2174/1570193043403055 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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