Solution-Phase Parallel Synthesis of N-Substituted Isoquinuclidines

Title: Solution-Phase Parallel Synthesis of N-Substituted Isoquinuclidines

Volume: 1 Issue: 4

Author(s): M. S. Levi, M. O.F. Khan and R. F. Borne

Affiliation:

Keywords: Ibogaine, isoquinuclidines, 2-azabicyclo[2.2.2]octanes, parallel synthesis, drug dependence

Abstract: The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 16-member library of N-substituted isoquinuclidines. A solution-phase method for their synthesis is described.

Cite this article as:

Levi S. M., Khan O.F. M. and Borne F. R., Solution-Phase Parallel Synthesis of N-Substituted Isoquinuclidines, Letters in Drug Design & Discovery 2004; 1 (4) . https://dx.doi.org/10.2174/1570180043398597