Abstract
The aim of the study was to investigate the effect of fenofibrate on the concentration and relative distribution of low density lipoprotein (LDL) subfractions in patients with combined dyslipidemia. Micronised fenofibrate was administered in a single daily dose of 200 mg. Serum lipid parameters and LDL subfraction concentrations were determined at baseline as well as after 16 weeks of treatment. Fenofibrate administration resulted in a significant decrease in total LDL mass. This decrease was due to the reduction in all LDL subfractions. As a consequence, the relative distribution of LDL subfractions was not affected by fenofibrate administration.
Keywords: fenofibrate, combined dyslipidemia, lipoprotein subfractions
Letters in Drug Design & Discovery
Title: Effect of Fenofibrate on the Concentration and Relative Distribution of LDL Subfractions in Patients with Combined Dyslipidemia
Volume: 1 Issue: 4
Author(s): V. Tsimihodimos, M. Elisaf, A. Tselepis, A. Tambaki and E. Bairaktari
Affiliation:
Keywords: fenofibrate, combined dyslipidemia, lipoprotein subfractions
Abstract: The aim of the study was to investigate the effect of fenofibrate on the concentration and relative distribution of low density lipoprotein (LDL) subfractions in patients with combined dyslipidemia. Micronised fenofibrate was administered in a single daily dose of 200 mg. Serum lipid parameters and LDL subfraction concentrations were determined at baseline as well as after 16 weeks of treatment. Fenofibrate administration resulted in a significant decrease in total LDL mass. This decrease was due to the reduction in all LDL subfractions. As a consequence, the relative distribution of LDL subfractions was not affected by fenofibrate administration.
Export Options
About this article
Cite this article as:
Tsimihodimos V., Elisaf M., Tselepis A., Tambaki A. and Bairaktari E., Effect of Fenofibrate on the Concentration and Relative Distribution of LDL Subfractions in Patients with Combined Dyslipidemia, Letters in Drug Design & Discovery 2004; 1 (4) . https://dx.doi.org/10.2174/1570180043398614
DOI https://dx.doi.org/10.2174/1570180043398614 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Gender Differences in the Effects of Angiotensin Receptor Blockers on Cardiovascular Disease
Current Pharmaceutical Design Aging is Not a Disorder
Current Aging Science Review of Cell and Organ Printing Patents
Recent Patents on Biomedical Engineering (Discontinued) Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer’s and Parkinson’s Diseases
Current Aging Science Confocal Laser Scanning Microscope, Raman Microscopy and Western Blotting to Evaluate Inflammatory Response after Myocardial Infarction
Current Vascular Pharmacology Clinical Value of Prostacyclin and its Analogs in the Management of Pulmonary Arterial Hypertension
Current Vascular Pharmacology Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage
Current Molecular Pharmacology Combinatorial Library Synthesis of Antioxidant Compounds
Combinatorial Chemistry & High Throughput Screening Nutraceutical: A Drug, Dietary Supplement and Food Ingredient
Current Pharmacogenomics and Personalized Medicine Metabolic Effects of Renal Denervation
Current Clinical Pharmacology Mitochondrially Targeted Antioxidants for the Treatment of Cardiovascular Diseases
Recent Patents on Cardiovascular Drug Discovery Current Biology of MTP: Implications for Selective Inhibition
Current Topics in Medicinal Chemistry Cross Talk Among Leukocytes, Platelets, and Endothelial Cells and its Relevance to Atherosclerosis and Coronary Heart Disease
Current Nutrition & Food Science Periodontal Muco-Adhesive Formulations for the Treatment of Infectious Periodontal Diseases
Current Drug Delivery The Anabolic Androgenic Steroid Testosterone Propionate Decreases Recognition Memory in Adult Male Rats
Current Psychopharmacology Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions
Current Medicinal Chemistry Statins in the Prevention of Cardiovascular Events in Patients with Renal Failure
Cardiovascular & Hematological Disorders-Drug Targets Valproate and Neuroendocrine Changes in Relation to Women Treated for Epilepsy and Bipolar Disorder: A Review
Current Medicinal Chemistry Saturation of the Human Phenome
Current Genomics Pulmonary Hypertension secondary to Left Heart Disease
Current Vascular Pharmacology