Abstract
Peripheral vascular disease can compromise the blood supply to the lower limb with amputation being necessary in severe cases. Reduced blood flow may be due to arterial occlusive disease or constriction of skeletal microvessels with the resultant ischaemia causing pain, tissue damage, ulceration and gangrene. These events are associated with endothelial damage or dysfunction: endothelin-1 is implicated as a mediator via its constrictor, proinflammatory and proliferative actions. Raised plasma and tissue levels of this peptide have been described in various ischaemic conditions, including peripheral vascular disease. Here, the possible role of endothelin-1 in peripheral vascular disease is discussed and potential therapeutic tools are considered.
Keywords: endothelin, receptors, ischaemia, reperfusion, vascular disease, pathology
Current Vascular Pharmacology
Title: A Role for Endothelin-1 in Peripheral Vascular Disease
Volume: 3 Issue: 4
Author(s): Janice C.S. Tsui and Michael R. Dashwood
Affiliation:
Keywords: endothelin, receptors, ischaemia, reperfusion, vascular disease, pathology
Abstract: Peripheral vascular disease can compromise the blood supply to the lower limb with amputation being necessary in severe cases. Reduced blood flow may be due to arterial occlusive disease or constriction of skeletal microvessels with the resultant ischaemia causing pain, tissue damage, ulceration and gangrene. These events are associated with endothelial damage or dysfunction: endothelin-1 is implicated as a mediator via its constrictor, proinflammatory and proliferative actions. Raised plasma and tissue levels of this peptide have been described in various ischaemic conditions, including peripheral vascular disease. Here, the possible role of endothelin-1 in peripheral vascular disease is discussed and potential therapeutic tools are considered.
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Cite this article as:
Tsui C.S. Janice and Dashwood R. Michael, A Role for Endothelin-1 in Peripheral Vascular Disease, Current Vascular Pharmacology 2005; 3 (4) . https://dx.doi.org/10.2174/157016105774329444
DOI https://dx.doi.org/10.2174/157016105774329444 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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