Mannich-type Reaction of Methylene Active Compounds with a Chiral Sulfinimine of Trifluoropyruvate: New Highly Stereoselective Synthesis of (S)-α-Trifluoromethyl-Aspartic Acid

Title: Mannich-type Reaction of Methylene Active Compounds with a Chiral Sulfinimine of Trifluoropyruvate: New Highly Stereoselective Synthesis of (S)-α-Trifluoromethyl-Aspartic Acid

Volume: 2 Issue: 3

Author(s): Francesco Lazzaro, Arnaud Gissot, Marcello Crucianelli, Francesco De Angelis, Luca Bruche and Matteo Zanda

Affiliation:

Keywords: fluorine, sulfinimines, mannich-reaction, trifluoromethyl amino acids, stereoselective synthesis

Abstract: A strongly improved, highly stereoselective synthesis of (S)-α-trifluoromethyl aspartic acid via addition of lithium malonate to a chiral sulfinimine of trifluoropyruvate is presented.

Cite this article as:

Lazzaro Francesco, Gissot Arnaud, Crucianelli Marcello, Angelis De Francesco, Bruche Luca and Zanda Matteo, Mannich-type Reaction of Methylene Active Compounds with a Chiral Sulfinimine of Trifluoropyruvate: New Highly Stereoselective Synthesis of (S)-α-Trifluoromethyl-Aspartic Acid, Letters in Organic Chemistry 2005; 2 (3) . https://dx.doi.org/10.2174/1570178053765348