Development of Organoiron Methodology for the C8-C16 Dienylamine Segment of the Streptogramin Antibiotics

Title: Development of Organoiron Methodology for the C8-C16 Dienylamine Segment of the Streptogramin Antibiotics

Volume: 2 Issue: 3

Author(s): Fahim Ahmed, Yeyu Cao and William A. Donaldson

Affiliation:

Keywords: streptogramin antibiotics, (diene)iron complexes, cyclocondensation

Abstract: Methodology for preparation of the C8-C16 dienylamine segment of the streptogramin antibiotics is based on a diastereoselective nitrile oxide-olefin cycloaddition to a (triene)iron complex. The Fe(CO)3 adjunct also serves as a protecting group for the subsequent reductive hydrolysis of the isoxazoline ring.

Cite this article as:

Ahmed Fahim, Cao Yeyu and Donaldson A. William, Development of Organoiron Methodology for the C8-C16 Dienylamine Segment of the Streptogramin Antibiotics, Letters in Organic Chemistry 2005; 2 (3) . https://dx.doi.org/10.2174/1570178053765366