Abstract
1,4-Benzothiazine (1,4-BT) derivatives have been reported to exhibit a wide range of pharmacological properties including antifungal, immunostimulating, anti-aldoso-reductase, anti-rheumatic, anti-allergic, vasorelaxant, anti-arrhythmic, anti-hypertensive, neuroprotective and cytotoxic activities. These different effects indicate that 1,4-BT is a template potentially useful in medicinal chemistry research and therapeutic applications.
Keywords: Candida infections, Rheumatoid arthritis, ALDOSE-REDUCTASE INHIBITORS, benzothiazepine nucleus, nimodipine, NEUROPROTECTIVE, anti-tumor
Mini-Reviews in Medicinal Chemistry
Title: Role of 1,4-Benzothiazine Derivatives in Medicinal Chemistry
Volume: 5 Issue: 12
Author(s): R. Fringuelli, L. Milanese and F. Schiaffella
Affiliation:
Keywords: Candida infections, Rheumatoid arthritis, ALDOSE-REDUCTASE INHIBITORS, benzothiazepine nucleus, nimodipine, NEUROPROTECTIVE, anti-tumor
Abstract: 1,4-Benzothiazine (1,4-BT) derivatives have been reported to exhibit a wide range of pharmacological properties including antifungal, immunostimulating, anti-aldoso-reductase, anti-rheumatic, anti-allergic, vasorelaxant, anti-arrhythmic, anti-hypertensive, neuroprotective and cytotoxic activities. These different effects indicate that 1,4-BT is a template potentially useful in medicinal chemistry research and therapeutic applications.
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Cite this article as:
Fringuelli R., Milanese L. and Schiaffella F., Role of 1,4-Benzothiazine Derivatives in Medicinal Chemistry, Mini-Reviews in Medicinal Chemistry 2005; 5 (12) . https://dx.doi.org/10.2174/138955705774933365
DOI https://dx.doi.org/10.2174/138955705774933365 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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