Abstract
There are pharmacological evidences that A2B receptors are involved in inflammatory processes, such as asthma. For this reason, many efforts has been made for identifying selective A2B antagonists as antiasthmatic agents. The updated material related to this field has been rationalised and arranged in order to offer an overview of the topic.
Keywords: endogenous nucleoside, adenosine receptors subtypes, protein Kinase C (PKC), Xanthine Derivatives, Triazolo-Triazine Derivatives, GPCRs
Mini-Reviews in Medicinal Chemistry
Title: A2B Adenosine Receptor Antagonists: Recent Developments
Volume: 5 Issue: 12
Author(s): Barbara Cacciari, Giorgia Pastorin, Chiara Bolcato, Giampiero Spalluto, Magdalena Bacilieri and Stefano Moro
Affiliation:
Keywords: endogenous nucleoside, adenosine receptors subtypes, protein Kinase C (PKC), Xanthine Derivatives, Triazolo-Triazine Derivatives, GPCRs
Abstract: There are pharmacological evidences that A2B receptors are involved in inflammatory processes, such as asthma. For this reason, many efforts has been made for identifying selective A2B antagonists as antiasthmatic agents. The updated material related to this field has been rationalised and arranged in order to offer an overview of the topic.
Export Options
About this article
Cite this article as:
Cacciari Barbara, Pastorin Giorgia, Bolcato Chiara, Spalluto Giampiero, Bacilieri Magdalena and Moro Stefano, A2B Adenosine Receptor Antagonists: Recent Developments, Mini-Reviews in Medicinal Chemistry 2005; 5 (12) . https://dx.doi.org/10.2174/138955705774933374
DOI https://dx.doi.org/10.2174/138955705774933374 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy
Current Medicinal Chemistry NLRP3 Inflammasome Activation Leading to IL-1 – IL-17 Dependent Lung Inflammation and Fibrosis
Current Respiratory Medicine Reviews Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Evaluation of Novel 7-(hetero)aryl-substituted Pyrazolo[1, 5-a]pyrimidines as Phosphodiesterase-4 Inhibitors
Letters in Drug Design & Discovery Multifaceted Synthesis, Properties and Applications of Polyurethanes and its Composites
Current Organic Chemistry Patent Selections
Recent Patents on Anti-Infective Drug Discovery Systems Biology Approaches to Pancreatic Cancer Detection, Prevention and Treatment
Current Pharmaceutical Design Clinical and Forensic Signs Related to Opioids Abuse
Current Drug Abuse Reviews Intraocular Delivery of Anti-Infective Drugs-Bacterial, Viral, Fungal and Parasitic
Recent Patents on Anti-Infective Drug Discovery Occupational Allergy in Healthcare Workers
Recent Patents on Inflammation & Allergy Drug Discovery Swertia chirata: A Comprehensive Review with Recent Advances
Current Pharmaceutical Biotechnology Acute Human Toxicity of Macrocyclic Lactones
Current Pharmaceutical Biotechnology Inflammatory Signaling Networks as Targets for Pharmacological Intervention of Chronic Diseases
Current Signal Transduction Therapy Shilajit (Mumie): Current Status of Biochemical, Therapeutic and Clinical Advances
Current Nutrition & Food Science Targeting Hypoxia-Inducible Factor-1 (HIF-1) Signaling in Therapeutics: Implications for the Treatment of Inflammatory Bowel Disease
Recent Patents on Inflammation & Allergy Drug Discovery The Association of Folic Acid Deficiency and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
Endocrine, Metabolic & Immune Disorders - Drug Targets Interaction of Small Molecules with Specific Immune Receptors: The p-i Concept and its Consequences
Current Immunology Reviews (Discontinued) Targeting the Human Thioredoxin System by Diverse Strategies to Treat Cancer and Other Pathologies
Recent Patents on DNA & Gene Sequences Epigenetic Regulation in Particulate Matter-Mediated Cardiopulmonary Toxicities: A Systems Biology Perspective
Current Pharmacogenomics and Personalized Medicine Fractional Exhaled Nitric Oxide and Nanomaterial Exposure in Workplaces
Current Medicinal Chemistry