Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Antiinflammatory 1,3,4-Thiadiazole Derivatives

Title: Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Antiinflammatory 1,3,4-Thiadiazole Derivatives

Volume: 2 Issue: 1

Author(s): L. S. Varandas, C. A.M. Fraga, A. L.P. Miranda and E. J. Barreiro

Affiliation:

Keywords: 1,3,4-thidiazole derivatives, anti-inflammatory activity, analgesic and antiplatelet properties

Abstract: In this work we reported the design, synthesis and evaluation of the anti-inflammatory, analgesic, and antiplatelet properties of new 1,3,4-thiadiazole derivatives, structurally planed by exploiting the molecular hybridization approach between diuretic drug acetazolamide and a 1,3-benzodioxole COX-2 inhibitor, previously developed. The in vivo pharmacological evaluation of these new compounds lead us to identify the para-fluoro-substituted derivative 8b as a new prototype, more active that celecoxib at the same molar concentration.

Cite this article as:

Varandas S. L., Fraga A.M. C., Miranda L.P. A. and Barreiro J. E., Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Antiinflammatory 1,3,4-Thiadiazole Derivatives, Letters in Drug Design & Discovery 2005; 2 (1) . https://dx.doi.org/10.2174/1570180053398235