Chiral Acetylenic Sulfoxide in Organic Synthesis: Addition of Chiral Secondary Amines

Title: Chiral Acetylenic Sulfoxide in Organic Synthesis: Addition of Chiral Secondary Amines

Volume: 2 Issue: 1

Author(s): Sujun Yan, K. T. Lam, K. T. Mo, W. Y. Wong, W. H. Chan and Albert W.M. Lee

Affiliation:

Keywords: chiral sulfoxide, asymmetric synthesis, alkaloid synthesis, diastereoselectivity

Abstract: Chiral secondary amines of the 3,4-dimethoxyphenylethyl and the tryptamine system were reacted with chiral acetylenic sulfoxides and achiral acetylenic sulfone. In the case of 3,4-dimethoxyphenylethyl amine, much improved diastereoselectivity (96 : 4) was observed as compared to the reaction of achiral secondary amine with chiral acetylenic sulfoxides.

Cite this article as:

Yan Sujun, Lam T. K., Mo T. K., Wong Y. W., Chan H. W. and Lee W.M. Albert, Chiral Acetylenic Sulfoxide in Organic Synthesis: Addition of Chiral Secondary Amines, Letters in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570178053400171