Abstract
Lipopolysaccharide (LPS) inhalation challenge is emerging as an experimental system for modeling environmental airway disease such as that seen in agricultural workers, and it can also serve as a model of environmental asthma. Mice exposed chronically to LPS develop all of the classical features of asthma including reversible airflow obstruction and inflammation, persistent airway hyperreactivity (AHR), and airway remodeling. Thickening and fibrosis of the subepithelial region of the airway wall is a consistent histologic feature of both environmental airway disease and of asthma that is directly related to the clinical severity of the disease. Lessons learned from such model systems may help to identify mechanisms that are fundamental to the development of chronic environmental airway disease and asthma.
Keywords: Asthma, LPS, airway remodeling, PMN, inflammation, TLR-4
Current Respiratory Medicine Reviews
Title: Milestones in the Development of Chronic LPS-Induced Airway Disease
Volume: 1 Issue: 3
Author(s): David M. Brass and Jordan D. Savov
Affiliation:
Keywords: Asthma, LPS, airway remodeling, PMN, inflammation, TLR-4
Abstract: Lipopolysaccharide (LPS) inhalation challenge is emerging as an experimental system for modeling environmental airway disease such as that seen in agricultural workers, and it can also serve as a model of environmental asthma. Mice exposed chronically to LPS develop all of the classical features of asthma including reversible airflow obstruction and inflammation, persistent airway hyperreactivity (AHR), and airway remodeling. Thickening and fibrosis of the subepithelial region of the airway wall is a consistent histologic feature of both environmental airway disease and of asthma that is directly related to the clinical severity of the disease. Lessons learned from such model systems may help to identify mechanisms that are fundamental to the development of chronic environmental airway disease and asthma.
Export Options
About this article
Cite this article as:
Brass M. David and Savov D. Jordan, Milestones in the Development of Chronic LPS-Induced Airway Disease, Current Respiratory Medicine Reviews 2005; 1 (3) . https://dx.doi.org/10.2174/157339805774597974
DOI https://dx.doi.org/10.2174/157339805774597974 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Modulating Co-Stimulation During Antigen Presentation to Enhance Cancer Immunotherapy
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Unravelling the Genetic Susceptibility to Develop Ligament and Tendon Injuries
Current Stem Cell Research & Therapy Targeting Strategies in Therapeutic Applications of Toxoplasmosis: Recent Advances in Liposomal Vaccine Delivery Systems
Current Drug Targets Mediterranean Diet and Longevity
Current Nutrition & Food Science Hydrogen Sulfide: A New Tool to Design and Develop Drugs
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) Proteases as Anti-Cancer Targets - Molecular and Biological Basis for Development of Inhibitor-Like Drugs Against Cancer
Anti-Cancer Agents in Medicinal Chemistry An Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-ones by Using Recyclable Wang Resin Supported Sulfonic Acid Catalyst
Letters in Organic Chemistry Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery C/EBP Transcription Factors in Lung Disease
Current Respiratory Medicine Reviews High Throughput Screening for Orphan and Liganded GPCRs
Combinatorial Chemistry & High Throughput Screening Periostin as a Heterofunctional Regulator of Cardiac Development and Disease
Current Genomics Idiopathic Pulmonary Fibrosis: An EU Patient Perspective Survey
Current Respiratory Medicine Reviews Cathelicidins: Peptides with Antimicrobial, Immunomodulatory, Anti- Inflammatory, Angiogenic, Anticancer and Procancer Activities
Current Protein & Peptide Science Antihistamines as Important Tools for Regulating Inflammation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents SARS-CoV-2: Molecular Biology and Therapeutic Targets
Coronaviruses Editorial (Mini-Thematic Issue: Mold Allergens and Antigenic Epitopes Correlation with Fungal Diseases)
Current Protein & Peptide Science Airway Fibrosis and Angiogenesis due to Eosinophil Trafficking in Chronic Asthma
Current Molecular Medicine Patent Selections :
Recent Patents on Cardiovascular Drug Discovery Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
Anti-Cancer Agents in Medicinal Chemistry Antioxidant Profile of Hyaluronan: Physico-Chemical Features and its Role in Pathologies
Mini-Reviews in Medicinal Chemistry