Abstract
CCAAT/enhancer binding proteins (C/EBPs) are key-regulators of cell differentiation and linked processes such as proliferation, apoptosis and gene expression in several organs. C/EBPs are also central for inflammatory responses and infectious defenses, but so far little is known of their role in lung diseases. However, a role for these intracellular proteins has recently been suggested in asthma, lung cancer and chronic bronchitis-COPD. In this mini-review, an overview of the biological roles of C/EBPs in lung is provided, together with a discussion of the recent studies suggesting a role for these transcription factors in the pathogenesis of some of our most common and severe lung diseases.
Keywords: Lung, CCAAT/enhancer binding proteins, transcription factors, lung cancer, asthma, chronic bronchitis, chronic obstructive pulmonary disease
Current Respiratory Medicine Reviews
Title: C/EBP Transcription Factors in Lung Disease
Volume: 1 Issue: 3
Author(s): Magnus Nord
Affiliation:
Keywords: Lung, CCAAT/enhancer binding proteins, transcription factors, lung cancer, asthma, chronic bronchitis, chronic obstructive pulmonary disease
Abstract: CCAAT/enhancer binding proteins (C/EBPs) are key-regulators of cell differentiation and linked processes such as proliferation, apoptosis and gene expression in several organs. C/EBPs are also central for inflammatory responses and infectious defenses, but so far little is known of their role in lung diseases. However, a role for these intracellular proteins has recently been suggested in asthma, lung cancer and chronic bronchitis-COPD. In this mini-review, an overview of the biological roles of C/EBPs in lung is provided, together with a discussion of the recent studies suggesting a role for these transcription factors in the pathogenesis of some of our most common and severe lung diseases.
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Cite this article as:
Nord Magnus, C/EBP Transcription Factors in Lung Disease, Current Respiratory Medicine Reviews 2005; 1 (3) . https://dx.doi.org/10.2174/157339805774597956
DOI https://dx.doi.org/10.2174/157339805774597956 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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