Abstract
Many issues regarding the definition, phenomenology, categorization and outcome of nonconvulsive (or dialeptic) status epilepticus are still unresolved. Management is often difficult, with highly variable response to treatment. This classically includes oral benzodiazepines or steroids. New insights into pathophysiological mechanisms involved in sustaining epileptic activity or deficits in seizure termination may lead to improved management programs. Relevant synaptic processes implicate functional alterations of GABA, GABA and NMDA receptor complexes. Early results with NMDA blockers (e.g. ketamine) in animal models and pediatric patients are encouraging. Metabolic approaches have included ketogenic diets. Dynamic approaches of electroencephalographic signals may open the way to neuromodulation through electrical resetting techniques applied at critical phases.
Keywords: Nonconvulsive, phenomenology, NMDA blockers, ketamine
Current Pediatric Reviews
Title: Nonconvulsive (Dialeptic) Status Epilepticus in Children
Volume: 1 Issue: 1
Author(s): Bernard Dan and Stewart G. Boyd
Affiliation:
Keywords: Nonconvulsive, phenomenology, NMDA blockers, ketamine
Abstract: Many issues regarding the definition, phenomenology, categorization and outcome of nonconvulsive (or dialeptic) status epilepticus are still unresolved. Management is often difficult, with highly variable response to treatment. This classically includes oral benzodiazepines or steroids. New insights into pathophysiological mechanisms involved in sustaining epileptic activity or deficits in seizure termination may lead to improved management programs. Relevant synaptic processes implicate functional alterations of GABA, GABA and NMDA receptor complexes. Early results with NMDA blockers (e.g. ketamine) in animal models and pediatric patients are encouraging. Metabolic approaches have included ketogenic diets. Dynamic approaches of electroencephalographic signals may open the way to neuromodulation through electrical resetting techniques applied at critical phases.
Export Options
About this article
Cite this article as:
Dan Bernard and Boyd G. Stewart, Nonconvulsive (Dialeptic) Status Epilepticus in Children, Current Pediatric Reviews 2005; 1 (1) . https://dx.doi.org/10.2174/1573396052953480
DOI https://dx.doi.org/10.2174/1573396052953480 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Identification of HIV Inhibitors Guided by Free Energy Perturbation Calculations
Current Pharmaceutical Design Heparanase Patents: Dim Past and Bright Future
Recent Patents on Inflammation & Allergy Drug Discovery Invasion and Egress by the Obligate Intracellular Parasite Toxoplasma gondii: Potential Targets for the Development of New Antiparasitic Drugs
Current Pharmaceutical Design Recent Patents on Proteasome Inhibitors of Natural Origin
Recent Patents on Anti-Cancer Drug Discovery Can Acetylcholinesterase Serve as a Target for Developing More Selective Insecticides?
Current Drug Targets CNS Drug Delivery Systems: Novel Approaches
Recent Patents on Drug Delivery & Formulation Innovative Methodology in the Discovery of Novel Drug Targets in the Free-Living Amoebae
Current Drug Targets Viral Encephalitis: Current Treatments and Future Perspectives
Central Nervous System Agents in Medicinal Chemistry Activation and Control of CNS Innate Immune Responses in Health and Diseases: A Balancing Act Finely Tuned by Neuroimmune Regulators (NIReg)
CNS & Neurological Disorders - Drug Targets Bridge Between Neuroimmunity and Traumatic Brain Injury
Current Pharmaceutical Design Isoform-Selective PI3K Inhibitors for Various Diseases
Current Topics in Medicinal Chemistry Sulfonamides: Antiviral Strategy for Neglected Tropical Disease Virus
Current Organic Chemistry Toll-Like Receptors and Inflammation in the CNS
Current Drug Targets - Inflammation & Allergy Immunoglobulin Free Light Chains in Immune Responses
Current Immunology Reviews (Discontinued) Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets Viral Encephalitis in Adults: A Narrative Review
Reviews on Recent Clinical Trials Cognitive Consequences of a Sustained Monocyte Type 1 IFN Response in HIV-1 Infection
Current HIV Research Current Opinions and Perspectives on the Role of Immune System in the Pathogenesis of Parkinson's Disease
Current Pharmaceutical Design Down with the Erythropoietin. Long Live the Erythropoietin !
Current Drug Targets Research Progress of Glycyrrhizic Acid on Antiviral Activity
Mini-Reviews in Medicinal Chemistry