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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Role of Endogenous Cannabinoids in Cognition and Emotionality

Author(s): Carsten T. Wotjak

Volume 5, Issue 7, 2005

Page: [659 - 670] Pages: 12

DOI: 10.2174/1389557054368763

Price: $65

Abstract

Novel pharmacological tools and the generation of null-mutants enabled the elucidation of the role of endocannabinoids in cognition and emotionality of rats and mice. Endocannabinoids seem to limit memory retention, to facilitate memory extinction and to ensure adequate coping with stressful situations. A selective potentiation of these actions may lead to novel pharmacotherapies for human anxiety disorders.

Keywords: learning, memory, review, anxiety, fear, stress, faah, cb, trpv, vr


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