Abstract
The RBCC (RING finger, B-box type zinc finger, coiled-coil domain) motif family contains a large number of proteins implicated in many cellular processes, including vesicle exocytosis. The acrosome reaction, the sperm exocytotic event that is required for fertilization, involves essentially the same process of intracellular membrane fusions as vesicular exocytosis in somatic cells. We have previously isolated a haploid-germ-cell-specific gene designated haprin, which encodes a RBCC motif protein that plays a role in the acrosome reaction of sperm by mediating protein complex formation via the RBCC motif. In this review, we describe the potential role of Haprin in the molecular mechanisms of acrosome reaction, as compared with some other RBCC proteins. The conserved structure and localization of the Haprin protein in human and mouse suggest an indispensable role for Haprin in the functioning of mammalian sperm.
Keywords: Infertility, testis, spermatogenesis, acrosome reaction, membrane fusion, RBCC/TRIM motif
Current Protein & Peptide Science
Title: The RING-Finger Protein Haprin: Domains and Function in the Acrosome Reaction
Volume: 6 Issue: 6
Author(s): Kouichi Kitamura, Hiromitsu Tanaka and Yoshitake Nishimune
Affiliation:
Keywords: Infertility, testis, spermatogenesis, acrosome reaction, membrane fusion, RBCC/TRIM motif
Abstract: The RBCC (RING finger, B-box type zinc finger, coiled-coil domain) motif family contains a large number of proteins implicated in many cellular processes, including vesicle exocytosis. The acrosome reaction, the sperm exocytotic event that is required for fertilization, involves essentially the same process of intracellular membrane fusions as vesicular exocytosis in somatic cells. We have previously isolated a haploid-germ-cell-specific gene designated haprin, which encodes a RBCC motif protein that plays a role in the acrosome reaction of sperm by mediating protein complex formation via the RBCC motif. In this review, we describe the potential role of Haprin in the molecular mechanisms of acrosome reaction, as compared with some other RBCC proteins. The conserved structure and localization of the Haprin protein in human and mouse suggest an indispensable role for Haprin in the functioning of mammalian sperm.
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Cite this article as:
Kitamura Kouichi, Tanaka Hiromitsu and Nishimune Yoshitake, The RING-Finger Protein Haprin: Domains and Function in the Acrosome Reaction, Current Protein & Peptide Science 2005; 6 (6) . https://dx.doi.org/10.2174/138920305774933277
DOI https://dx.doi.org/10.2174/138920305774933277 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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