Effect of Additional Chiral Ligands in Catalytic Enantioselective Addition of Ketene Silyl Acetals to Nitrones

Title: Effect of Additional Chiral Ligands in Catalytic Enantioselective Addition of Ketene Silyl Acetals to Nitrones

Volume: 2 Issue: 4

Author(s): P. Merino, S. Franco, P. Jimenez, T. Tejero and M. A. Chiacchio

Affiliation:

Keywords: nitrones, hydroxylamines, aminoacids, mannich reaction

Abstract: The enantioselectivity of the titanium (IV)-BINOL catalyzed asymmetric Mannich-type reactions of nitrones can be enhanced by using additional chiral ligands. The best results are obtained with diols derived from D-mannitol.

Cite this article as:

Merino P., Franco S., Jimenez P., Tejero T. and Chiacchio A. M., Effect of Additional Chiral Ligands in Catalytic Enantioselective Addition of Ketene Silyl Acetals to Nitrones, Letters in Organic Chemistry 2005; 2 (4) . https://dx.doi.org/10.2174/1570178054038803