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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Identification of Privileged Scaffolds from a Diversified Chemical Library forβ-Secretase Inhibition

Author(s): Nicolas Pietrancosta, Gilles Quelever, Cedrik Garino, Younes Laras, Stephane Burlet and Jean-Louis Kraus

Volume 2, Issue 8, 2005

Page: [595 - 600] Pages: 6

DOI: 10.2174/157018005774717352

Price: $65

Abstract

A privileged structure has been identified within the 1,300-member diversified library by rational selection of the compounds to be tested prior to the screening towards enzymatic β-secretase (BACE-1) assay. The identified hexahydrobenzothiazole privileged structure has been optimised and a preliminary structureactivity study has been performed.

Keywords: Diversified chemical library, screening, privileged structure, β-secretase (BACE-1), Alzheimer's disease, hexahydrobenzothiazole


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