Abstract
Lactoferrin is a secreted protein related to transferrin. Lactoferrin indirectly protects host cells against foreign insults by killing bacteria, scavenging free iron, and binding to receptors required for viral invasion. However, lactoferrin is also proposed to act directly on cells as a transcription factor and tumor suppressor gene. In addition to full length lactoferrin, a truncated form, called delta lactoferrin, can also be produced by alternative splicing. We show here that transformed and nontransformed cells are equally able to express both full length and delta lactoferrin. Moreover, both forms of lactoferrin failed to substantially modulate the expression of other genes. Thus, lactoferrin does not seem to directly control gene expression or inhibit tumor cell growth.
Keywords: lactoferrin, glycoprotein, expression, tumor, transcripts
Medicinal Chemistry
Title: Full Length and Delta Lactoferrin Display Differential Cell Localization Dynamics, but do not Act as Tumor Markers or Significantly Affect the Expression of Other Genes
Volume: 1 Issue: 1
Author(s): Gary S. Goldberg, Takehiko Kunimoto, David B. Alexander, Kayoko Suenaga, Fumiyoshi Ishidate, Kazuaki Miyamoto, Toshikazu Ushijima, Christina T. Teng, Jun Yokota, Tsutomu Ohta and Hiroyuki Tsuda
Affiliation:
Keywords: lactoferrin, glycoprotein, expression, tumor, transcripts
Abstract: Lactoferrin is a secreted protein related to transferrin. Lactoferrin indirectly protects host cells against foreign insults by killing bacteria, scavenging free iron, and binding to receptors required for viral invasion. However, lactoferrin is also proposed to act directly on cells as a transcription factor and tumor suppressor gene. In addition to full length lactoferrin, a truncated form, called delta lactoferrin, can also be produced by alternative splicing. We show here that transformed and nontransformed cells are equally able to express both full length and delta lactoferrin. Moreover, both forms of lactoferrin failed to substantially modulate the expression of other genes. Thus, lactoferrin does not seem to directly control gene expression or inhibit tumor cell growth.
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Goldberg S. Gary, Kunimoto Takehiko, Alexander B. David, Suenaga Kayoko, Ishidate Fumiyoshi, Miyamoto Kazuaki, Ushijima Toshikazu, Teng T. Christina, Yokota Jun, Ohta Tsutomu and Tsuda Hiroyuki, Full Length and Delta Lactoferrin Display Differential Cell Localization Dynamics, but do not Act as Tumor Markers or Significantly Affect the Expression of Other Genes, Medicinal Chemistry 2005; 1 (1) . https://dx.doi.org/10.2174/1573406053402532
DOI https://dx.doi.org/10.2174/1573406053402532 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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