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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Three Components Coupling Catalysed by Na2CaP2O7: Synthesis of α-Amino Phosphonates Under Solvent-Free Conditions at Room Temperature

Author(s): M. Zahouily, A. Elmakssoudi, A. Mezdar, A. Rayadh, S. Sebti and H. B. Lazrek

Volume 2, Issue 5, 2005

Page: [428 - 432] Pages: 5

DOI: 10.2174/1570178054405887

Price: $65

Abstract

Synthetic phosphate Na2CaP2O7 has been utilized as an efficient catalyst for the three components coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphite to produce α-amino phosphonates. The reaction was carried out under solvent-free conditions at room temperature. The by-product H2O formed during the reaction increases the catalytic activity of Na2CaP2O7.

Keywords: synthetic phosphate, amino phosphonates, heterogeneous catalysis, recyclable catalyst


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