Sulphamic Acid (H2NSO3H) Catalysed One Pot Synthesis of 3,4-Dihydropyrimidin-2(1h)-Ones and their Thione Analogues

Title: Sulphamic Acid (H2NSO3H) Catalysed One Pot Synthesis of 3,4-Dihydropyrimidin-2(1h)-Ones and their Thione Analogues

Volume: 2 Issue: 7

Author(s): S. A. Kotharkar, M. R. Jadhav, R. R. Nagawade, S. S. Bahekar and D. B. Shinde

Affiliation:

Keywords: sulphamic acid, catalyst, biginelli reaction

Abstract: The substituted 3,4-dihydropyrimidin-2(1H)-ones and their thione analogues have been prepared Via Biginelli condensation using aldehyde, 1,3-dicarbonyl compound and urea or thiourea under the catalyst of sulphamic acid (H2NSO3H). The method is simple, cost-effective, and gives good yields in a shorter reaction time.

Cite this article as:

Kotharkar A. S., Jadhav R. M., Nagawade R. R., Bahekar S. S. and Shinde B. D., Sulphamic Acid (H2NSO3H) Catalysed One Pot Synthesis of 3,4-Dihydropyrimidin-2(1h)-Ones and their Thione Analogues, Letters in Organic Chemistry 2005; 2 (7) . https://dx.doi.org/10.2174/157017805774296830