Abstract
The enaminones represent potentially useful agents for the clinical treatment in generalized tonic-clonic seizures (Epilepsia, 1993, 34(6), 1141-1145, Biopharm. Drug Disp. 2003, 397-407). A regression analysis was performed to provide a quantitative structure-activity relationship (QSAR) correlation model for prediction of activity for the anticonvulsant enaminones. Molecular modeling was performed to determine the molecular confluence of the Unverferth model (J. Med. Chem. 1998, 41, 63-73) to the enaminones. Conclusions related to the sodium channel model were assessed.
Keywords: epilepsy, sodium channel, anticonvulsants, molecular modeling, regression analysis
Medicinal Chemistry
Title: QSAR of the Anticonvulsant Enaminones; Molecular Modeling Aspects and other Assessments
Volume: 1 Issue: 4
Author(s): T. L. Wilson, P. L. Jackson, C. D. Hanson, Z. Xue, N. D. Eddington and K. R. Scott
Affiliation:
Keywords: epilepsy, sodium channel, anticonvulsants, molecular modeling, regression analysis
Abstract: The enaminones represent potentially useful agents for the clinical treatment in generalized tonic-clonic seizures (Epilepsia, 1993, 34(6), 1141-1145, Biopharm. Drug Disp. 2003, 397-407). A regression analysis was performed to provide a quantitative structure-activity relationship (QSAR) correlation model for prediction of activity for the anticonvulsant enaminones. Molecular modeling was performed to determine the molecular confluence of the Unverferth model (J. Med. Chem. 1998, 41, 63-73) to the enaminones. Conclusions related to the sodium channel model were assessed.
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Cite this article as:
Wilson L. T., Jackson L. P., Hanson D. C., Xue Z., Eddington D. N. and Scott R. K., QSAR of the Anticonvulsant Enaminones; Molecular Modeling Aspects and other Assessments, Medicinal Chemistry 2005; 1 (4) . https://dx.doi.org/10.2174/1573406054368710
DOI https://dx.doi.org/10.2174/1573406054368710 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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