Abstract
BnSP-7 and BnSP-6, two Lys49-phospholipase A2 isolated from Bothrops neuwiedi pauloensis snake venom, were co-crystallized with α-tocopherol and X-ray diffraction data were collected for both complexes (2.2 and 2.6 Å). A new "alternative" quaternary conformation for these two complexes compared with all other dimeric Lys49-PLA2 has been observed.
Keywords: crystallization, x-ray crystallography, lys-phospholipase a, bothrops neuwiedi venom, myotoxity, tocopherol
Protein & Peptide Letters
Title: Crystallization and Preliminary X-Ray Diffraction Studies of Two Myotoxic Lys49-Phospholipases A2 Complexed with α-Tocopherol
Volume: 12 Issue: 8
Author(s): Juliana I. dos Santos, Agnes A.S. Takeda, Daniela P. Marchi-Salvador, Andreimar M. Soares and Marcos R.M. Fontes
Affiliation:
Keywords: crystallization, x-ray crystallography, lys-phospholipase a, bothrops neuwiedi venom, myotoxity, tocopherol
Abstract: BnSP-7 and BnSP-6, two Lys49-phospholipase A2 isolated from Bothrops neuwiedi pauloensis snake venom, were co-crystallized with α-tocopherol and X-ray diffraction data were collected for both complexes (2.2 and 2.6 Å). A new "alternative" quaternary conformation for these two complexes compared with all other dimeric Lys49-PLA2 has been observed.
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Cite this article as:
dos Santos I. Juliana, Takeda A.S. Agnes, Marchi-Salvador P. Daniela, Soares M. Andreimar and Fontes R.M. Marcos, Crystallization and Preliminary X-Ray Diffraction Studies of Two Myotoxic Lys49-Phospholipases A2 Complexed with α-Tocopherol, Protein & Peptide Letters 2005; 12 (8) . https://dx.doi.org/10.2174/0929866054864283
DOI https://dx.doi.org/10.2174/0929866054864283 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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