Abstract
5-Hydroxytyptophan is a fluorescent tryptophan analog that can be incorporated into recombinant proteins expressed in E. coli and is particularly useful in studies of biological systems that involve supermolecular aggregates of more than one protein. Here we review the varied applications of 5-hydroxytryptophan to study structure, interactions, conformational change and dynamics in complex protein systems.
Keywords: 5-hydroxytryptophan, tryptophan, fluorescence, protein structure, protein-protein interactions, protein folding
Protein & Peptide Letters
Title: Using 5-Hydroxytryptophan as a Probe to Follow Protein-Protein Interactions and Protein Folding Transitions
Volume: 12 Issue: 3
Author(s): Fernando Correa and Chuck S. Farah
Affiliation:
Keywords: 5-hydroxytryptophan, tryptophan, fluorescence, protein structure, protein-protein interactions, protein folding
Abstract: 5-Hydroxytyptophan is a fluorescent tryptophan analog that can be incorporated into recombinant proteins expressed in E. coli and is particularly useful in studies of biological systems that involve supermolecular aggregates of more than one protein. Here we review the varied applications of 5-hydroxytryptophan to study structure, interactions, conformational change and dynamics in complex protein systems.
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Cite this article as:
Correa Fernando and Farah S. Chuck, Using 5-Hydroxytryptophan as a Probe to Follow Protein-Protein Interactions and Protein Folding Transitions, Protein & Peptide Letters 2005; 12 (3) . https://dx.doi.org/10.2174/0929866053587057
DOI https://dx.doi.org/10.2174/0929866053587057 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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