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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

A Quantitative Structure-Activity Relationship Study on Some Na+ and K+ Channel Blockers: Role of Molecular Connectivity Index

Author(s): S. P. Gupta, Anitha Paleti, S. B. Mekapati, A. N. Nagappa and S. Kumaran

Volume 2, Issue 4, 2005

Page: [287 - 290] Pages: 4

DOI: 10.2174/1570180054038422

Price: $65

Abstract

A quantitative structure-activity relationship (QSAR) study is made on a series of Na+ channel blockers (diphenylacetamide derivatives) and on a series of K+ channel blockers (blockers of cardiac delayed rectifier potassium current IKs) (benzodiazepine derivatives). In both the cases, the blocking activity is found to be significantly correlated with Kiers first-order valence molecular connectivity index.

Keywords: channel blockers, qsar, connectivity index


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