Abstract
A series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.
Keywords: Isoniazid, tuberculosis, antimycobacterial activity
Letters in Drug Design & Discovery
Title: Synthesis and Anti-Mycobacterial Activity of N-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives
Volume: 2 Issue: 7
Author(s): Ivan N. Junior, Maria C. S. Lourenco, Maria das Gracas M. O. Henriques, Barbara Ferreira, Thatyana R. A. Vasconcelos, Monica A. Peralta, Pedro S. M. de Oliveira, Solange M. S. V. Wardell and Marcus V. N. de Souza
Affiliation:
Keywords: Isoniazid, tuberculosis, antimycobacterial activity
Abstract: A series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.
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Junior N. Ivan, Lourenco C. S. Maria, Henriques M. O. Maria das Gracas, Ferreira Barbara, Vasconcelos R. A. Thatyana, Peralta A. Monica, de Oliveira S. M. Pedro, Wardell M. S. V. Solange and de Souza V. N. Marcus, Synthesis and Anti-Mycobacterial Activity of N-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives, Letters in Drug Design & Discovery 2005; 2 (7) . https://dx.doi.org/10.2174/157018005774479131
DOI https://dx.doi.org/10.2174/157018005774479131 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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