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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Anti-Mycobacterial Activity of N-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives

Author(s): Ivan N. Junior, Maria C. S. Lourenco, Maria das Gracas M. O. Henriques, Barbara Ferreira, Thatyana R. A. Vasconcelos, Monica A. Peralta, Pedro S. M. de Oliveira, Solange M. S. V. Wardell and Marcus V. N. de Souza

Volume 2, Issue 7, 2005

Page: [563 - 566] Pages: 4

DOI: 10.2174/157018005774479131

Price: $65

Abstract

A series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.

Keywords: Isoniazid, tuberculosis, antimycobacterial activity


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