Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives

Title: Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives

Volume: 2 Issue: 7

Author(s): Jose M. Padron, David Tejedor, Alicia Santos-Exposito, Fernando Garcia-Tellado, Jesus Villar and Victor S. Martin

Affiliation:

Keywords: Pyrroles, diversity-oriented synthesis, privileged structure, breast cancer, SU11248, tyrosine kinase inhibitors

Abstract: A series of tetrasubstituted pyrrole derivatives, structurally related to tyrosine kinase inhibitors, has been synthesized one-pot by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. The compounds were evaluated for their anticancer activities using the human breast cancer cell lines, T-47D and MCF7.

Cite this article as:

Padron M. Jose, Tejedor David, Santos-Exposito Alicia, Garcia-Tellado Fernando, Villar Jesus and Martin S. Victor, Synthesis and Anti-Breast Cancer Activity of Tetrasubstituted Pyrrole Derivatives, Letters in Drug Design & Discovery 2005; 2 (7) . https://dx.doi.org/10.2174/157018005774479122