Abstract
A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.
Keywords: Ruthenium-catalysis, tocopherols, isoprenoids, E/Z selectivity, homo-coupling
Current Topics in Medicinal Chemistry
Title: Cross-Metathesis: Efficient Preparation of Trialkyl-Substituted Isoprenoid Olefins as Key-Intermediates for Tocopherol Synthesis
Volume: 5 Issue: 15
Author(s): Thomas Netscher
Affiliation:
Keywords: Ruthenium-catalysis, tocopherols, isoprenoids, E/Z selectivity, homo-coupling
Abstract: A summary of the application of ruthenium catalyzed olefin cross-metathesis towards the synthesis of tocopherols (vitamin E) is given. This group of biologically important fat-soluble antioxidants is synthetically available by various routes, for which key-intermediates containing trialkyl-substituted olefinic double bonds can now be prepared efficiently. The results presented may be of interest for the area of syntheses of isoprenoid natural products in general.
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Cite this article as:
Netscher Thomas, Cross-Metathesis: Efficient Preparation of Trialkyl-Substituted Isoprenoid Olefins as Key-Intermediates for Tocopherol Synthesis, Current Topics in Medicinal Chemistry 2005; 5 (15) . https://dx.doi.org/10.2174/156802605775009775
DOI https://dx.doi.org/10.2174/156802605775009775 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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