Abstract
Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.
Keywords: Sortase, antibiotic, anti-infective, Staphylococcus aureus, gram-positive bacteria, inhibitor, SrtA
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances Towards New Anti-Infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-Positive Pathogens
Volume: 7 Issue: 10
Author(s): N. Suree, M. E. Jung and R. T. Clubb
Affiliation:
Keywords: Sortase, antibiotic, anti-infective, Staphylococcus aureus, gram-positive bacteria, inhibitor, SrtA
Abstract: Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.
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Suree N., Jung E. M. and Clubb T. R., Recent Advances Towards New Anti-Infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-Positive Pathogens, Mini-Reviews in Medicinal Chemistry 2007; 7 (10) . https://dx.doi.org/10.2174/138955707782110097
DOI https://dx.doi.org/10.2174/138955707782110097 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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