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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Advances Towards New Anti-Infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-Positive Pathogens

Author(s): N. Suree, M. E. Jung and R. T. Clubb

Volume 7, Issue 10, 2007

Page: [991 - 1000] Pages: 10

DOI: 10.2174/138955707782110097

Price: $65

Abstract

Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family.

Keywords: Sortase, antibiotic, anti-infective, Staphylococcus aureus, gram-positive bacteria, inhibitor, SrtA


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