Asymmetric Aldol Additions with a Titanium Enolate of N-Thioglycolyl Oxazolidinethione

Title: Asymmetric Aldol Additions with a Titanium Enolate of N-Thioglycolyl Oxazolidinethione

Volume: 4 Issue: 7

Author(s): Aurelio Ortiz, Rocio Sabala, Estibaliz Sansinenea and Sylvain Bernes

Affiliation:

Keywords: Asymmetric aldol additions, titanium enolates, oxazolidinethione

Abstract: A titanium enolate of N-thioglycolyl oxazolidinethione has been prepared and used for the synthesis of "Evans" syn aldol adducts, in good yield and high selectivity. Removal of the chiral auxiliary was accomplished by reduction to the corresponding 1,3-diols or by preparation of Weinreb amides.

Cite this article as:

Ortiz Aurelio, Sabala Rocio, Sansinenea Estibaliz and Bernes Sylvain, Asymmetric Aldol Additions with a Titanium Enolate of N-Thioglycolyl Oxazolidinethione, Letters in Organic Chemistry 2007; 4 (7) . https://dx.doi.org/10.2174/157017807782006380