Abstract
The scope of 6,8-dioxa-3-aza-bicyclo(3.2.1)octane derivatives as morpholine replacing groups in bioactive compounds was investigated. Four derivatives were synthesized and subjected to the routinary screening strategy, as part of a project directed to obtain new tachykinin NK2 antagonists. The obtained results encourage further study on the heterobicycle 6,8-dioxa-3-aza-bicyclo(3.2.1)octane as morpholine surrogate.
Keywords: Tachykinins, Neurokinin A, 6,8-dioxa-3-aza-bicyclo(3.2.1)octane, Morpholine, Oligomer
Letters in Drug Design & Discovery
Title: First In Vivo Evaluation of a New Morpholine Analog
Volume: 4 Issue: 7
Author(s): M. Altamura, A. Guidi, F. Pasqui, M. Tramontana and K. Worm-Leonhard
Affiliation:
Keywords: Tachykinins, Neurokinin A, 6,8-dioxa-3-aza-bicyclo(3.2.1)octane, Morpholine, Oligomer
Abstract: The scope of 6,8-dioxa-3-aza-bicyclo(3.2.1)octane derivatives as morpholine replacing groups in bioactive compounds was investigated. Four derivatives were synthesized and subjected to the routinary screening strategy, as part of a project directed to obtain new tachykinin NK2 antagonists. The obtained results encourage further study on the heterobicycle 6,8-dioxa-3-aza-bicyclo(3.2.1)octane as morpholine surrogate.
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Cite this article as:
Altamura M., Guidi A., Pasqui F., Tramontana M. and Worm-Leonhard K., First In Vivo Evaluation of a New Morpholine Analog, Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788534
DOI https://dx.doi.org/10.2174/157018007781788534 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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