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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

First In Vivo Evaluation of a New Morpholine Analog

Author(s): M. Altamura, A. Guidi, F. Pasqui, M. Tramontana and K. Worm-Leonhard

Volume 4, Issue 7, 2007

Page: [520 - 523] Pages: 4

DOI: 10.2174/157018007781788534

Price: $65

Abstract

The scope of 6,8-dioxa-3-aza-bicyclo(3.2.1)octane derivatives as morpholine replacing groups in bioactive compounds was investigated. Four derivatives were synthesized and subjected to the routinary screening strategy, as part of a project directed to obtain new tachykinin NK2 antagonists. The obtained results encourage further study on the heterobicycle 6,8-dioxa-3-aza-bicyclo(3.2.1)octane as morpholine surrogate.

Keywords: Tachykinins, Neurokinin A, 6,8-dioxa-3-aza-bicyclo(3.2.1)octane, Morpholine, Oligomer


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