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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Preparation of Orthogonally-Protected 3-Methoxy-4-Phosphonomethyl-LPhenylalanine,a New Reagent for the Synthesis of Phosphotyrosyl Mimetic-Containing Peptides

Author(s): W.J. Choi, S.-U. Kang and T.R. Burke Jr.

Volume 4, Issue 6, 2007

Page: [433 - 439] Pages: 7

DOI: 10.2174/157017807781467614

Price: $65

Abstract

[(4-Hydroxymethyl-2-methoxyphenyl)methyl]phosphonic acid di-tert-butyl ester (8) served as a key intermediate in the stereoselective preparation of N-Fmoc-3-methoxy-4-(di-tert-butyl)phosphonomethyl-L-phenylalanine (5). Reagent 5 may be useful for the solid-phase synthesis of phosphotyrosyl mimetic-containing peptides.

Keywords: Amino acid, asymmetric, chiral auxiliaries, peptides, stereoselective synthesis


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