Abstract
Bronchiolitis Obliterans (OB) is a potentially life threatening, uncommon, but severe form of chronic obstructive lung disease in children, that results from lower airway injury following a respiratory infection. Clinically, it is characterized by rapid respirations, rales, wheezing and hypoxemia for at least 30 days after the initial injury. Histologically, OB is characterized by luminal obstruction with inflammation, granulation tissue, fibrosis and obliteration of the small airways and bronchiectasis. A number of respiratory viruses such as respiratory syncytial virus (RSV), parainfluenza, and particularly adenovirus are associated with severe lung injury leading to OB. This mini-review will seek to provide an up to date, concise review of the currently available literature and research, in the area of adenovirus associated Bronchiolitis Obliterans in children.
Keywords: peak tidal expiratory flow, functional residual capacity, impulse oscillometry technique, high resolution computed tomography, constrictive bronchiolitis
Current Pediatric Reviews
Title: Adenovirus and Post-Infectious Bronchiolitis Obliterans in Children
Volume: 3 Issue: 3
Author(s): Amrita Dosanjh
Affiliation:
Keywords: peak tidal expiratory flow, functional residual capacity, impulse oscillometry technique, high resolution computed tomography, constrictive bronchiolitis
Abstract: Bronchiolitis Obliterans (OB) is a potentially life threatening, uncommon, but severe form of chronic obstructive lung disease in children, that results from lower airway injury following a respiratory infection. Clinically, it is characterized by rapid respirations, rales, wheezing and hypoxemia for at least 30 days after the initial injury. Histologically, OB is characterized by luminal obstruction with inflammation, granulation tissue, fibrosis and obliteration of the small airways and bronchiectasis. A number of respiratory viruses such as respiratory syncytial virus (RSV), parainfluenza, and particularly adenovirus are associated with severe lung injury leading to OB. This mini-review will seek to provide an up to date, concise review of the currently available literature and research, in the area of adenovirus associated Bronchiolitis Obliterans in children.
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Cite this article as:
Amrita Dosanjh , Adenovirus and Post-Infectious Bronchiolitis Obliterans in Children, Current Pediatric Reviews 2007; 3 (3) . https://dx.doi.org/10.2174/157339607781369519
DOI https://dx.doi.org/10.2174/157339607781369519 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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