Abstract
We describe synthesis of α-methylated analogues of the natural polyamines and their use as tools in unraveling polyamine functions. Experiments with α-methylated spermidine and spermine revealed that the polyamines are exchangeable in supporting cellular growth. Degradation of the analogues by polyamine oxidase disclosed hidden, aldehydeguided stereospecificity of the enzyme.
Keywords: Hypusine, liver regeneration, pancreatitis, polyamine oxidase, spermidine/spermine N1-acetyltransferase, stereospecificity, transgenic
Mini-Reviews in Medicinal Chemistry
Title: α-Methylated Polyamines as Potential Drugs and Experimental Tools in Enzymology
Volume: 7 Issue: 8
Author(s): Tuomo A. Keinanen, Aki Jarvinen, Anne Uimari, Jouko Vepsalainen, Alex R. Khomutov, Nikolay A. Grigorenko, Mervi T. Hyvonen, Marc Cerrada-Gimenez, Leena Alhonen and Juhani Janne
Affiliation:
Keywords: Hypusine, liver regeneration, pancreatitis, polyamine oxidase, spermidine/spermine N1-acetyltransferase, stereospecificity, transgenic
Abstract: We describe synthesis of α-methylated analogues of the natural polyamines and their use as tools in unraveling polyamine functions. Experiments with α-methylated spermidine and spermine revealed that the polyamines are exchangeable in supporting cellular growth. Degradation of the analogues by polyamine oxidase disclosed hidden, aldehydeguided stereospecificity of the enzyme.
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Tuomo A. Keinanen , Aki Jarvinen , Anne Uimari , Jouko Vepsalainen , Alex R. Khomutov , Nikolay A. Grigorenko , Mervi T. Hyvonen , Marc Cerrada-Gimenez , Leena Alhonen and Juhani Janne , α-Methylated Polyamines as Potential Drugs and Experimental Tools in Enzymology, Mini-Reviews in Medicinal Chemistry 2007; 7 (8) . https://dx.doi.org/10.2174/138955707781387867
DOI https://dx.doi.org/10.2174/138955707781387867 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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