Abstract
The synthesis of new triphenyltin derivatives with (N-substituted-pyrazol-3-yl) carboxylic acid fragments is described. The in vitro antibacterial activity of the new agents was evaluated against two fungal strains (Saccharomyces cerevisiae and Fusarium oxysporum f.sp albedinis) and against bacterial strains (Echerichia coli). A considerable activity was recorded with respect to the three studied micro-organisms. Structure activity relationship studies (SAR) reflect the effect of substituted pyrazolic fragment.
Keywords: Pyrazolic acids, Triphenyltin derivatives, Biological activities
Letters in Drug Design & Discovery
Title: Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids
Volume: 4 Issue: 5
Author(s): Abderrahmane Yahyi, Abdelkader Ettouhami, Smaail Radi, Ismail Zidane, Abdelkader Hakkou and Mohamed Bouakka
Affiliation:
Keywords: Pyrazolic acids, Triphenyltin derivatives, Biological activities
Abstract: The synthesis of new triphenyltin derivatives with (N-substituted-pyrazol-3-yl) carboxylic acid fragments is described. The in vitro antibacterial activity of the new agents was evaluated against two fungal strains (Saccharomyces cerevisiae and Fusarium oxysporum f.sp albedinis) and against bacterial strains (Echerichia coli). A considerable activity was recorded with respect to the three studied micro-organisms. Structure activity relationship studies (SAR) reflect the effect of substituted pyrazolic fragment.
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Yahyi Abderrahmane, Ettouhami Abdelkader, Radi Smaail, Zidane Ismail, Hakkou Abdelkader and Bouakka Mohamed, Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids, Letters in Drug Design & Discovery 2007; 4 (5) . https://dx.doi.org/10.2174/157018007780867889
DOI https://dx.doi.org/10.2174/157018007780867889 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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