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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics

Author(s): James A. Wilkinson, Steven B. Rossington, Nicholas A. Coe, Nicholas Hirst, Alan T. McGown, John Leonard and Nigel Hussain

Volume 4, Issue 4, 2007

Page: [246 - 248] Pages: 3

DOI: 10.2174/157018007784620068

Price: $65

Abstract

A series of novel, 2-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.

Keywords: Fendiline, Antileukemic compounds, Diphenylmethanes


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