Synthesis and Binding Properties of New Endothelin Receptor Ligands

Title: Synthesis and Binding Properties of New Endothelin Receptor Ligands

Volume: 4 Issue: 3

Author(s): Maria Modica, Loredana Salerno, Valeria Pittala, Giuseppe Romeo, Mariangela Siracusa, Ilario Mereghetti, Alfredo Cagnotto and Tiziana Mennini

Affiliation:

Keywords: Hypertension, Endothelins, G protein-coupled receptors, ET receptors, Benzenesulfonamides, Binding properties

Abstract: In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ETAh and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6- trimethylphenyl)benzamide (23) was the most interesting.

Cite this article as:

Modica Maria, Salerno Loredana, Pittala Valeria, Romeo Giuseppe, Siracusa Mariangela, Mereghetti Ilario, Cagnotto Alfredo and Mennini Tiziana, Synthesis and Binding Properties of New Endothelin Receptor Ligands, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077426