Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid

Title: Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid

Volume: 3 Issue: 12

Author(s): Dibakar Goswami and Angshuman Chattopadhyay

Affiliation:

Keywords: Alzheimer disease, arundic acid, (R)-2,3-cyclohexylideneglyceraldehyde, crotylation, propargyl alcohol, stereoselectivity, ozonolysis, enantiopurity

Abstract: (R)-Arundic acid 15 was prepared in a simple manner and with absolute optical purity via Cu and Fe mediated and Luches crotylation of 1 with bromides 6a,b. Co wasnt a good mediator for these crotylation reactions. The stereoselectivity for all crotylations were similar producing mainly 7b, c, besides a small amount of 7a.

Cite this article as:

Goswami Dibakar and Chattopadhyay Angshuman, Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779468059