Abstract
A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.
Keywords: Cholesterylated carboxylic acid, oligo(ethylene glycols), targeting ligand, gene delivery
Letters in Organic Chemistry
Title: Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery
Volume: 3 Issue: 12
Author(s): Xiaochun Wu, Yong Wu, Li Hai and Ying Bao
Affiliation:
Keywords: Cholesterylated carboxylic acid, oligo(ethylene glycols), targeting ligand, gene delivery
Abstract: A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.
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Cite this article as:
Wu Xiaochun, Wu Yong, Hai Li and Bao Ying, Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779468004
DOI https://dx.doi.org/10.2174/157017806779468004 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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