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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery

Author(s): Xiaochun Wu, Yong Wu, Li Hai and Ying Bao

Volume 3, Issue 12, 2006

Page: [911 - 914] Pages: 4

DOI: 10.2174/157017806779468004

Price: $65

Abstract

A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.

Keywords: Cholesterylated carboxylic acid, oligo(ethylene glycols), targeting ligand, gene delivery


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