Signal Transduction Therapy of Diabetic Vascular Complication

Author(s): Sho-ichi Yamagishi, Kazuo Nakamura, Takanori Matsui, Yumiko Yoshida, Katsuhiko Takenaka, Yuko Jinnouchi, Tsutomu Imaizumi

Journal Name: Current Signal Transduction Therapy

Volume 2 , Issue 1 , 2007

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Diabetic vascular complication is a leading cause of end-stage renal failure, acquired blindness, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. There is a growing body of evidence to conclude that intensive control of plasma glucose and blood pressure is crucial for effectively reducing diabetic vascular complication. So far, various molecular mechanisms have been proposed to play a role in the development and progression of diabetic vascular complication. In this paper, we review potential therapeutic strategies for the prevention of diabetic vascular complication, especially focusing on the signal transduction pathways activated under diabetes.

Keywords: Advanced glycation end products, diabetic vascular complication, oxidative stress, enin-angiotensin system

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Article Details

Year: 2007
Page: [91 - 100]
Pages: 10
DOI: 10.2174/157436207779317100

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