Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines

Title: Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines

Volume: 4 Issue: 2

Author(s): Luiz Everson da Silva, Antonio Carlos Joussef, Leticia Kramer Pacheco, Danielle Bibas Legat Albino, Anita Mauricio Camilo Duarte, Mario Steindel and Ricardo Andrade Rebelo

Affiliation:

Keywords: Chloronaphthyridines, Antiparasitic, Trypanocidal and Leishmanicidal activities

Abstract: The leishmanicidal and trypanocidal activities of chlorinated 1,7- and 1,8-naphthyridines were evaluated against cultured of L. amazonensis promastigote and T. cruzi epimastigote forms. Active compounds were also tested against blood trypomastigotes and their toxicity to Vero cells. Among the compounds evaluated 10 was the most active against L. amazonensis promastigotes and T. cruzi epimastigotes, IC50= 8.6 μM and IC50 =20.4 μM, respectively.

Cite this article as:

Everson da Silva Luiz, Carlos Joussef Antonio, Kramer Pacheco Leticia, Bibas Legat Albino Danielle, Mauricio Camilo Duarte Anita, Steindel Mario and Andrade Rebelo Ricardo, Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines, Letters in Drug Design & Discovery 2007; 4 (2) . https://dx.doi.org/10.2174/157018007779422550