Abstract
3D-QSAR methodologies represent a useful, widespread tool in drug discovery and optimisation. Here we introduce an alternative QSAR tool for model generation: the non-linear Response Surface Analysis, that finds at present great application in Design of Experiment for optimizing drug production processes. Binding affinity estimation of human A3 adenosine receptor antagonists is considered as key study.
Keywords: 3D-QSAR, Response Surface Analysis, Adenosine receptors
Letters in Drug Design & Discovery
Title: Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study
Volume: 4 Issue: 2
Author(s): Magdalena Bacilieri, Chosei Kaseda, Giampiero Spalluto and Stefano Moro
Affiliation:
Keywords: 3D-QSAR, Response Surface Analysis, Adenosine receptors
Abstract: 3D-QSAR methodologies represent a useful, widespread tool in drug discovery and optimisation. Here we introduce an alternative QSAR tool for model generation: the non-linear Response Surface Analysis, that finds at present great application in Design of Experiment for optimizing drug production processes. Binding affinity estimation of human A3 adenosine receptor antagonists is considered as key study.
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Bacilieri Magdalena, Kaseda Chosei, Spalluto Giampiero and Moro Stefano, Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study, Letters in Drug Design & Discovery 2007; 4 (2) . https://dx.doi.org/10.2174/157018007779422460
DOI https://dx.doi.org/10.2174/157018007779422460 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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