Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line

Title: Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line

Volume: 14 Issue: 1

Author(s): Akikazu Sakudo, Izuru Nakamura, Deug-Chan Lee, Keiichi Saeki, Kazuyoshi Ikuta and Takashi Onodera

Affiliation:

Keywords: Prion disease, prion protein (PrP), apoptosis, PrP-deficient cell line, PrP(106-126)

Abstract: The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.

Cite this article as:

Sakudo Akikazu, Nakamura Izuru, Lee Deug-Chan, Saeki Keiichi, Ikuta Kazuyoshi and Onodera Takashi, Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line, Protein & Peptide Letters 2007; 14 (1) . https://dx.doi.org/10.2174/0929866510707010001