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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Carbohydrate Antigens: Synthesis Aspects and Immunological Applications in Cancer

Author(s): Teresa Freire, Sylvie Bay, Sophie Vichier-Guerre, Richard Lo-Man and Claude Leclerc

Volume 6, Issue 12, 2006

Page: [1357 - 1373] Pages: 17

DOI: 10.2174/138955706778992996

Price: $65

Abstract

Tumor Associated Carbohydrate Antigens (TACAs) constitute powerful tools as tumor markers and as targets for anticancer immunotherapy. In this review, methods of production of glycopeptide-based vaccines, as well as results of preclinical and clinical studies in cancer patients are discussed.

Keywords: Glycosylation, cancer, glycosyltransferase, synthesis, vaccine, immunotherapy, carbohydrate


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