Abstract
There appear to be compelling evidences presenting adiponectin as a key regulator of energy homeostasis. Over the past 10 years, much work has been done to identify the molecular mechanisms by which adiponectin functions in the body. We and other groups have demonstrated that adiponectin activates multiple signaling pathways, which mediate its anti-diabetic, anti-atherogenic and anti-inflammatory functions. Comprehensive analysis of the mechanism of adiponectin action may allow us to elucidate the etiology of metabolic syndrome associated diseases including diabetes and cardiovascular diseases, where dysfunction of adiponectin may contribute to pathogenesis of diseases. While regulation of adiponectin gene expression or secretion remains an interesting topic in studies of cell metabolism, further intensive studies are necessary to illustrate the molecular mechanisms. Importantly, identification of molecules in the adiponectin signaling pathways and in the regulation of adiponectin gene expression may provide novel targets for therapeutic drugs.
Keywords: Adiponectin, signal transduction, insulin, insulin sensitivity, obesity, diabetes
Mini-Reviews in Medicinal Chemistry
Title: The Adiponectin Signaling Pathway as a Novel Pharmacological Target
Volume: 6 Issue: 12
Author(s): Xuming Mao, Jenny Y. Hong and Lily Q. Dong
Affiliation:
Keywords: Adiponectin, signal transduction, insulin, insulin sensitivity, obesity, diabetes
Abstract: There appear to be compelling evidences presenting adiponectin as a key regulator of energy homeostasis. Over the past 10 years, much work has been done to identify the molecular mechanisms by which adiponectin functions in the body. We and other groups have demonstrated that adiponectin activates multiple signaling pathways, which mediate its anti-diabetic, anti-atherogenic and anti-inflammatory functions. Comprehensive analysis of the mechanism of adiponectin action may allow us to elucidate the etiology of metabolic syndrome associated diseases including diabetes and cardiovascular diseases, where dysfunction of adiponectin may contribute to pathogenesis of diseases. While regulation of adiponectin gene expression or secretion remains an interesting topic in studies of cell metabolism, further intensive studies are necessary to illustrate the molecular mechanisms. Importantly, identification of molecules in the adiponectin signaling pathways and in the regulation of adiponectin gene expression may provide novel targets for therapeutic drugs.
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Cite this article as:
Mao Xuming, Hong Y. Jenny and Dong Q. Lily, The Adiponectin Signaling Pathway as a Novel Pharmacological Target, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778992978
DOI https://dx.doi.org/10.2174/138955706778992978 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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