Abstract
Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.
Keywords: Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species
Mini-Reviews in Medicinal Chemistry
Title: New Insights into the Regulation of Liver Inflammation and Oxidative Stress
Volume: 6 Issue: 12
Author(s): Natalia Ferre and Joan Claria
Affiliation:
Keywords: Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species
Abstract: Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.
Export Options
About this article
Cite this article as:
Ferre Natalia and Claria Joan, New Insights into the Regulation of Liver Inflammation and Oxidative Stress, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778993049
DOI https://dx.doi.org/10.2174/138955706778993049 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sigma-1 Receptors: Potential Targets for the Treatment of Substance Abuse
Current Pharmaceutical Design Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies
Current Pharmaceutical Design Angiogenic Growth Factors in the Treatment of Peripheral Arterial Disease
Current Vascular Pharmacology Cardiac MRI in Autoimmune Diseases: Where Are We Now?
Current Cardiology Reviews Ebola Virus Altered Innate and Adaptive Immune Response Signalling Pathways: Implications for Novel Therapeutic Approaches
Infectious Disorders - Drug Targets The Clinical Evaluation of Chronic Cough
Current Respiratory Medicine Reviews Leptin and Vascular Smooth Muscle
Current Vascular Pharmacology Melatonin Role in Experimental Arthritis
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Cyclooxygenases Regulation by Estradiol on Endothelium
Current Pharmaceutical Design Evolving Insights into the Pathophysiology of Diabetic Neuropathy: Implications of Malfunctioning Glia and Discovery of Novel Therapeutic Targets
Current Pharmaceutical Design Incretin Pharmacology: A Review of the Incretin Effect and Current Incretin-Based Therapies
Cardiovascular & Hematological Agents in Medicinal Chemistry Neurocysticercosis: The Enigmatic Disease
Central Nervous System Agents in Medicinal Chemistry The Involvement of Norepinephrine in Behaviors Related to Psychostimulant Addiction
Current Neuropharmacology Biologics and the Cardiovascular System: A Double-Edged Sword
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Phage Display Technique: Advantages and Recent Patents
Recent Patents on DNA & Gene Sequences Autoimmune Neuromuscular Disorders
Current Neuropharmacology Clinical Implications of Non-Invasive Measurement of Central Aortic Blood Pressure
Current Vascular Pharmacology Lymphoid-Specific Tyrosine Phosphatase (Lyp): A Potential Drug Target For Treatment of Autoimmune Diseases
Current Drug Targets Focus on the Multimodal Role of Biomarkers in Breast Cancer
Current Pharmaceutical Design Role of Alpha-1 Antitrypsin (AAT) in Ocular Allergy and Uveitis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry