Abstract
The increasing drug resistance of malaria parasites against chemotherapeutics enforces new strategies in finding new drugs. Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A).
Keywords: Hypusine, dipyridyl-piperidone carbonic esters, antiplasmodial, initiation factor eIF-5A, deoxyhypusine synthase (DHS)
Mini-Reviews in Medicinal Chemistry
Title: Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria
Volume: 6 Issue: 11
Author(s): A. Kaiser, D. Ulmer, T. Goebel, U. Holzgrabe, M. Saeftel and A. Hoerauf
Affiliation:
Keywords: Hypusine, dipyridyl-piperidone carbonic esters, antiplasmodial, initiation factor eIF-5A, deoxyhypusine synthase (DHS)
Abstract: The increasing drug resistance of malaria parasites against chemotherapeutics enforces new strategies in finding new drugs. Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A).
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Cite this article as:
Kaiser A., Ulmer D., Goebel T., Holzgrabe U., Saeftel M. and Hoerauf A., Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria, Mini-Reviews in Medicinal Chemistry 2006; 6 (11) . https://dx.doi.org/10.2174/138955706778742795
DOI https://dx.doi.org/10.2174/138955706778742795 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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