Abstract
Amyloid β-protein (Aβ) plays a pivotal role in Alzheimers disease (AD). Therapeutic strategies inhibiting Aβ aggregation and promoting extracellular Aβ removal are currently advocated. Here, we review recent literature on intracellular Aβ, especially intranuclear Aβ, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Aβ-related pathogenesis.
Keywords: Alzheimer's disease, amyloid β-protein, intracellular, intranuclear, Aβ-related Death Inducing Protein, p53, promoter, apoptosis, amyloid -protein, related Death Inducing Protein
Mini-Reviews in Medicinal Chemistry
Title: Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease
Volume: 6 Issue: 10
Author(s): Yasumasa Ohyagi and Takeshi Tabira
Affiliation:
Keywords: Alzheimer's disease, amyloid β-protein, intracellular, intranuclear, Aβ-related Death Inducing Protein, p53, promoter, apoptosis, amyloid -protein, related Death Inducing Protein
Abstract: Amyloid β-protein (Aβ) plays a pivotal role in Alzheimers disease (AD). Therapeutic strategies inhibiting Aβ aggregation and promoting extracellular Aβ removal are currently advocated. Here, we review recent literature on intracellular Aβ, especially intranuclear Aβ, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Aβ-related pathogenesis.
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Cite this article as:
Ohyagi Yasumasa and Tabira Takeshi, Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560175
DOI https://dx.doi.org/10.2174/138955706778560175 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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