Abstract
The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.
Keywords: CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine
Current Topics in Medicinal Chemistry
Title: Selective Agents for Serotonin2C (5-HT2C) Receptor
Volume: 6 Issue: 18
Author(s): Enza Lacivita and Marcello Leopoldo
Affiliation:
Keywords: CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine
Abstract: The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.
Export Options
About this article
Cite this article as:
Lacivita Enza and Leopoldo Marcello, Selective Agents for Serotonin2C (5-HT2C) Receptor, Current Topics in Medicinal Chemistry 2006; 6 (18) . https://dx.doi.org/10.2174/156802606778522168
DOI https://dx.doi.org/10.2174/156802606778522168 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Microextraction by Packed Sorbent of B Vitamins from Energy Bev erages Prior to Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry Assay
Current Chromatography Crosstalk Between Covid-19 and Associated Neurological Disorders: A Review
Current Neuropharmacology Manufacturing of Orthodontic Brackets: A Review of Metallurgical Perspectives and Applications
Recent Patents on Materials Science Amphetamine-Type Medicines: A Review of Pharmacokinetics, Pharmacodynamics, and Toxicological Aspects.
Current Clinical Pharmacology A Short Review of Diffusion Models and their Possibilities to Enhance Imaging Biomarkers for Neurodegenerative Diseases
Current Medical Imaging Glycogen Synthase Kinase-3 in Neurodegeneration and Neuroprotection:Lessons from Lithium
Current Alzheimer Research The Overlap Between Binge Eating Behaviors and Polycystic Ovarian Syndrome: An Etiological Integrative Model
Current Pharmaceutical Design Pathogenesis and Treatment of Secondary Hyperparathyroidism in Dialysis Patients: The Role of Paricalcitol
Current Vascular Pharmacology Structure-based Vaccine Design in HIV: Blind Men and the Elephant?
Current Pharmaceutical Design Myeloperoxidase: The Good, the Bad, and the Ugly
Current Immunology Reviews (Discontinued) Depression and Disturbed Bone Metabolism: A Narrative Review of the Epidemiological Findings and Postulated Mechanisms
Current Molecular Medicine Endogenous Ligand Bias by Chemokines: Implications at the Front Lines of Infection and Leukocyte Trafficking
Endocrine, Metabolic & Immune Disorders - Drug Targets Derivation of Motor Neurons from three Clonal Human Embryonic Stem Cell Lines
Current Neurovascular Research Patent Selections:
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery
Mini-Reviews in Medicinal Chemistry HDAC Inhibitors-New Generation of Target Specific Treatment
Mini-Reviews in Medicinal Chemistry Ketamine Induces Toxicity in Human Neurons Differentiated from Embryonic Stem Cells via Mitochondrial Apoptosis Pathway
Current Drug Safety GC-MS Analysis of Essential Oil from Lavandula angustifolia Cultivated in Garhwal Himalaya
The Natural Products Journal Exploring Novel Approaches to Vaginal Drug Delivery
Recent Patents on Drug Delivery & Formulation Exposure to Perinatal Infections and Bipolar Disorder: A Systematic Review
Current Molecular Medicine